Importance of the lipid peroxidation biomarkers and methodological aspects FOR malondialdehyde quantification

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Importance of the lIpId peroxIdatIon bIomarkers and methodologIcal aspects for malondIaldehyde quantIfIcatIon

denise grotto, lucas santa maria, Juliana Valentini, clóvis paniz, gabriela schmitt e solange cristina garcia* Departamento de Análises Cínicas e Toxicológicas, Universidade Federal de Santa Maria, CP 5061, 97110-970 Santa Maria RS, Brasil Valdeci Juarez pomblum Departamento de Clínica Médica, Universidade Federal de Santa Maria, 97110-970 Santa Maria RS, Brasil João batista t. rocha Departamen...

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Pathological aspects of lipid peroxidation.

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the patho...

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Biomarqueurs de la peroxydation lipidique : aspects analytiques Biomarkers of lipid peroxidation: analytical aspects

During these last years, oxidative stress has been implicated in various pathological situations. The difficulty is to choose a convenient marker to appreciate its importance in vivo because of analytical problems of specificity and sensitivity. The oxidized lipids, formed during lipid peroxidation, illustrate these problems. Among these markers are ‘primary’ products such as hydroperoxides, or...

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Lipid peroxidation products as oxidative stress biomarkers.

Oxidative stress induced by reactive oxygen and nitrogen species has been implicated in the pathogenesis of various disorders and diseases. Biomarkers are needed for assessment of oxidative stress status in vivo and also for health examination, diagnosis at early stage, prognosis, safe and efficient drug development, and evaluation of efficacy of drugs, foods, beverages, and supplements. Lipids...

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ژورنال

عنوان ژورنال: Química Nova

سال: 2009

ISSN: 0100-4042

DOI: 10.1590/s0100-40422009000100032